Learning Together: Localism, Collaboration and Reflexivity in the Development of Prison and University Learning Communities

This paper engages with challenges of localism, collaboration and reflexivity in thinking about the conceptualisation and development of partnership learning communities between higher education and criminal justice institutions. Grounded in experiences of partnership working in the UK and Australia, our arguments are twofold: first, drawing on missions, policy and practice challenges, that there is a case to be made for partnership-working between higher education and criminal justice institutions; and second that, although there is a need to think about collaborative international structures, there is also a need to reflect critically on how different socio-political and cultural realities (both within and beyond national borders) might shape the particular nature of partnership working. Therefore, while warmly welcoming international collaboration in this field, we urge caution in importing or exporting different models of partnership working. We make the case, instead, for open-textured theoretical and empirical reflexivity

Learning Together: Localism, Collaboration and Reflexivity in the Development of Prison and University Learning Communities

This paper engages with challenges of localism, collaboration and reflexivity in thinking about the conceptualisation and development of partnership learning communities between higher education and criminal justice institutions. Grounded in experiences of partnership working in the UK and Australia, our arguments are twofold: first, drawing on missions, policy and practice challenges, that there is a case to be made for partnership-working between higher education and criminal justice institutions; and second that, although there is a need to think about collaborative international structures, there is also a need to reflect critically on how different socio-political and cultural realities (both within and beyond national borders) might shape the particular nature of partnership working. Therefore, while warmly welcoming international collaboration in this field, we urge caution in importing or exporting different "models" of partnership working. We make the case, instead, for open-textured theoretical and empirical reflexivity

Neural Organization of A3 Mushroom Body Extrinsic Neurons in the Honeybee Brain

In the insect brain, the mushroom body is a higher order brain area that is key to memory formation and sensory processing. Mushroom body (MB) extrinsic neurons leaving the output region of the MB, the lobes and the peduncle, are thought to be especially important in these processes. In the honeybee brain, a distinct class of MB extrinsic neurons, A3 neurons, are implicated in playing a role in learning. Their MB arborisations are either restricted to the lobes and the peduncle, here called A3 lobe connecting neurons, or they provide feedback information from the lobes to the input region of the MB, the calyces, here called A3 feedback neurons. In this study, we analyzed the morphology of individual A3 lobe connecting and feedback neurons using confocal imaging. A3 feedback neurons were previously assumed to innervate each lip compartment homogenously. We demonstrate here that A3 feedback neurons do not innervate whole subcompartments, but rather innervate zones of varying sizes in the MB lip, collar, and basal ring. We describe for the first time the anatomical details of A3 lobe connecting neurons and show that their connection pattern in the lobes resemble those of A3 feedback cells. Previous studies showed that A3 feedback neurons mostly connect zones of the vertical lobe that receive input from Kenyon cells of distinct calycal subcompartments with the corresponding subcompartments of the calyces. We can show that this also applies to the neck of the peduncle and the medial lobe, where both types of A3 neurons arborize only in corresponding zones in the calycal subcompartments. Some A3 lobe connecting neurons however connect multiple vertical lobe areas. Contrarily, in the medial lobe, the A3 neurons only innervate one division. We found evidence for both input and output areas in the vertical lobe. Thus, A3 neurons are more diverse than previously thought. The understanding of their detailed anatomy might enable us to derive circuit models for learning and memory and test physiological data

Cooperative Learning Supported by Telecooperation

Die Telekooperation bietet neue Möglichkeiten der Lernunterstützung durch die Integration von Informations- und Kommunikationstechnologien zu multimedialen Lernumgebungen. Die Lernwirkung lässt sich am Arbeitsplatz vervielfachen, indem die Vorteile konventioneller Methoden wie Selbstlernen mittels CBT durch tutorielle Unterstützung über Kommunikationsverbindung erheblich gesteigert werden. In dem folgenden Beitrag werden zunächst die Ziele der Telekooperation insbesondere im Hinblick auf ihre Konsequenzen für die Weiterbildung herausgearbeitet. Daran schließt sich eine Erläuterung der technischen Möglichkeiten der Telekooperation an, die durch ein Szenario zum Fernlernen und die Vorstellung der ECOLE-Lernumgebung veranschaulicht werden. Abschließend zeigt eine Zusammenfassung die zu erwartenden technologischen Entwicklungen im Hinblick auf die Weiterbildung. (DIPF/Orig.)Telecooperation offers new possibilities for learning support due to the integration of information and communication technologies into multimedia learning environments. The learning effort via desktop can be multiplied by combining conventional methods like self-learning based on CBT with a collaborative remote tutor support. This paper first explains the objectives of telecooperation especially with a view to the consequences for further education. Then an explanation of the technical possibilities of telecooperation follows. They are clarified with the help of a scenario for distance learning and the presentation of the ECOLE learning environment. Finally a conclusion shows the technological developments we may expect with regard to further education. (DIPF/Orig.

Memory enhancement by ferulic acid ester across species

Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2E)-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea–derived FAE-20. Here, we show that both R. rosea–derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila. Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea—the plant from which we discovered FAE-20—as a memory enhancer, these results may hold potential for clinical applications

Neural Organization of A3 Mushroom Body Extrinsic Neurons in the Honeybee Brain

In the insect brain, the mushroom body is a higher order brain area that is key to memory formation and sensory processing. Mushroom body (MB) extrinsic neurons leaving the output region of the MB, the lobes and the peduncle, are thought to be especially important in these processes. In the honeybee brain, a distinct class of MB extrinsic neurons, A3 neurons, are implicated in playing a role in learning. Their MB arborisations are either restricted to the lobes and the peduncle, here called A3 lobe connecting neurons, or they provide feedback information from the lobes to the input region of the MB, the calyces, here called A3 feedback neurons. In this study, we analyzed the morphology of individual A3 lobe connecting and feedback neurons using confocal imaging. A3 feedback neurons were previously assumed to innervate each lip compartment homogenously. We demonstrate here that A3 feedback neurons do not innervate whole subcompartments, but rather innervate zones of varying sizes in the MB lip, collar, and basal ring. We describe for the first time the anatomical details of A3 lobe connecting neurons and show that their connection pattern in the lobes resemble those of A3 feedback cells. Previous studies showed that A3 feedback neurons mostly connect zones of the vertical lobe that receive input from Kenyon cells of distinct calycal subcompartments with the corresponding subcompartments of the calyces. We can show that this also applies to the neck of the peduncle and the medial lobe, where both types of A3 neurons arborize only in corresponding zones in the calycal subcompartments. Some A3 lobe connecting neurons however connect multiple vertical lobe areas. Contrarily, in the medial lobe, the A3 neurons only innervate one division. We found evidence for both input and output areas in the vertical lobe. Thus, A3 neurons are more diverse than previously thought. The understanding of their detailed anatomy might enable us to derive circuit models for learning and memory and test physiological data

Learning and Its Neural Correlates in a Virtual Environment for Honeybees

The search for neural correlates of operant and observational learning requires a combination of two (experimental) conditions that are very difficult to combine: stable recording from high order neurons and free movement of the animal in a rather natural environment. We developed a virtual environment (VE) that simulates a simplified 3D world for honeybees walking stationary on an air-supported spherical treadmill. We show that honeybees perceive the stimuli in the VE as meaningful by transferring learned information from free flight to the virtual world. In search for neural correlates of learning in the VE, mushroom body extrinsic neurons were recorded over days during learning. We found changes in the neural activity specific to the rewarded and unrewarded visual stimuli. Our results suggest an involvement of the mushroom body extrinsic neurons in operant learning in the honeybee (Apis mellifera)

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat the disease. However, HA is also implicated in normal physiology. Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by a tet-response element promoter to understand the role of HA in systemic metabolism. To our surprise, adipocyte-specific overproduction of HA leads to smaller adipocytes and protects mice from high-fat-high-sucrose-diet-induced obesity and glucose intolerance. Adipocytes also have more free glycerol that can be released upon beta3 adrenergic stimulation. Improvements in glucose tolerance were not linked to increased plasma HA. Instead, an HA-driven systemic substrate redistribution and adipose tissue-liver crosstalk contributes to the systemic glucose improvements. In summary, we demonstrate an unexpected improvement in glucose metabolism as a consequence of HA overproduction in adipose tissue, which argues against the use of systemic HA synthesis inhibitors to treat obesity and T2D

Who Represents the Poor? The Corrective Potential of Populism in Spain

Scholarly research assumes populism enhances democratic inclusion by giving voice to groups that are not represented by political elites and by obliging them to be more attentive to their preferences. Empirical studies have focused on this dynamic more indirectly looking at the emergence of new conflict dimensions, leaving the representation of marginalised groups underexplored. This article contributes to filling this gap by analysing party competition over poverty responsiveness at the regional level in Spain during the Great Recession. Combining Regional Manifestos Project data with issue sub-categorisation, the article shows that populist parties, which emerged during the economic crisis, represent the poor to a greater degree in their political agenda than establishment parties. At the same time, the latter have reacted to new competitors by being more attentive to the poor in their political discourse. As a result, supply-side adaption to include proposals tackling poverty and social exclusion increased the representation of the poor in regional spaces of political competition

The Scottish Early Rheumatoid Arthritis (SERA) Study:an inception cohort and biobank

Background: The Scottish Early Rheumatoid Arthritis (SERA) study is an inception cohort of rheumatoid (RA) and undifferentiated arthritis (UA) patients that aims to provide a contemporary description of phenotype and outcome and facilitate discovery of phenotypic and prognostic biomarkers Methods: Demographic and clinical outcome data are collected from newly diagnosed RA/UA patients every 6 months from around Scotland. Health service utilization data is acquired from Information Services Division, NHS National Services Scotland. Plain radiographs of hands and feet are collected at baseline and 12 months. Additional samples of whole blood, plasma, serum and filtered urine are collected at baseline, 6 and 12 months Results: Results are available for 1073 patients; at baseline, 76 % were classified as RA and 24 % as UA. Median time from onset to first review was 163 days (IQR97-323). Methotrexate was first-line DMARD for 75 % patients. Disease activity, functional ability and health-related quality of life improved significantly between baseline and 24 months, however the proportion in any employment fell (51 to 38 %, p = 0.0005). 24 % patients reported symptoms of anxiety and/or depression at baseline. 35/391 (9 %) patients exhibited rapid radiographic progression after 12 months. The SERA Biobank has accrued 60,612 samples Conclusions: In routine care, newly diagnosed RA/UA patients experience significant improvements in disease activity, functional ability and health-related quality of life but have high rates of psychiatric symptoms and declining employment rates. The co-existence of a multi-domain description of phenotype and a comprehensive biobank will facilitate multi-platform translational research to identify predictive markers of phenotype and prognosis